Antioxidant Therapy in Nonalcoholic Steatohepatitis
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Antioxidant Therapy in Nonalcoholic Steatohepatitis
Nonalcoholic steatohepatitis (NASH) affects up to 3% of the North American population. It occurs as a manifestation of the insulin-resistant state and oxidative stress is thought to be a key component of its pathophysiology. Exercise and diet, which are the mainstay of therapy, are difficult to achieve and maintain with a disappointing long-term compliance record. There is growing literature on...
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The increasing prevalence of obesity, insulin resistance, and the metabolic syndrome has significant implications for the future of chronic liver disease. The resultant increase in the number of patients with nonalcoholic fatty liver disease (NAFLD) is expected to translate into increased numbers of patients with end-stage liver disease (cirrhosis), liver failure, and hepatocellular carcinoma. ...
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Nonalcoholic fatty liver disease (NAFLD) is being increasingly recognized as a common liver disorder that represents the hepatic manifestation of the metabolic syndrome, a variably defined aggregate of disorders related to obesity, insulin resistance, type II diabetes, hypertension and hyperlipidemia. Nonalcoholic steatohepatitis (NASH) is the progressive form of liver injury that carries a ris...
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Figure 1. Necroptosis is activated in human nonalcoholic steatohepatitis (NASH) samples. Representative immunohistochemical staining for phospho-MLKL on livers from different controls (Ctl) and NASH patients. Note the specific granular cytoplasmatic staining. See Gautheron et al for the specifics of the NASH cohort as well as the technical and ethical aspects. Dear Editor: One fundamental step ...
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*KURAに登録されているコンテンツの利用については,著作権法に規定されている私的使用や引用などの範囲内で行ってください。 *著作権法に規定されている私的使用や引用などの範囲を超える利用を行う場合には,著作権者の許諾を得てください。ただし,著作権者 から著作権等管理事業者(学術著作権協会,日本著作出版権管理システムなど)に権利委託されているコンテンツの利用手続については ,各著作権等管理事業者に確認してください。 Title Pioglitazone in Nonalcoholic Steatohepatitis Author(s) Ota, Tsuguhito; Takamura, Toshinari; Kaneko, Shuichi Citation New England Journal of Medicine, 356(10): 1067-1069 Issue Date 20...
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ژورنال
عنوان ژورنال: Hepatitis Research and Treatment
سال: 2012
ISSN: 2090-1364,2090-1372
DOI: 10.1155/2012/947575